康替唑胺体外抗菌作用研究

目的 评价唑烷酮类新药康替唑胺对临床分离菌的体外抗菌作用.方法 收集全国19所医院1321株的临床分离菌,以琼脂对倍稀释法测定康替唑胺对分离菌的最低抑菌浓度(MIC)并与有关抗菌药物进行比较,测定康替唑胺的杀菌活性、抗菌药物后效应(PAE)以及不同培养条件对康替唑胺抗菌作用的影响.结果 康替唑胺对革兰阳性菌中葡萄球菌...

In vitro activities of contezolid against clinical isolates from China

Objective To evaluate the in vitro antimicrobial activities of contezolid.Methods This study examined the full range in vitro antimicrobial activity of contezolid and comparators against 1321 clinical bacterial strains using two-fold agar dilution method.Contezolid was also characterized in terms of bactericidal activity,post-antibiotic effect(PAE)and the effect of culture conditions on susceptibility testing.Results The results of antimicrobial susceptibility testing supported the high antimicrobial activity of contezolid against gram-positive bacteria,including multidrug resistant strains such as methicillin-resistant S.aureus(MRSA),penicillin-resistant S.pneumoniae(PRSP),and vancomycin-resistant Enterococcus(VRE).Contezolid was slightly more potent than linezolid,teicoplanin,and vancomycin in the activity against Staphylococcus.For Streptococcus,the activity of contezolid was comparable to linezolid,but slightly lower than vancomycin and teicoplanin.Contezolid and linezolid showed similar high activity against Enterococcus regardless of their susceptibility profile to vancomycin.Contezolid displayed good bactericidal activity against S.pneumoniae but bacteriostatic effect on Enterococcus strains.The average PAE of contezolid was about(1.56±0.42)h for S.aureus and(1.77±0.99)h for S.pneumoniae.Inoculum size and serum protein concentration in the testing media,but not changing pH of media,affected the in vitro activity of contezolid.Conclusions This pharmacodynamic study demonstrates that contezolid as a novel oxazolidinone antibiotic,has potent in vitro antimicrobial activities against the gram-positive bacteria tested,including MRSA,methicillin-resistant coagulase-negative Staphylococcus,PRSP,and VRE;bactericidal activity against MRSA and PRSP strains,and longer PAE.These findings suggest that contezolid will play an important role in treating the infections caused by gram-positive bacteria,especially the multidrug-resistant strains.It is expected to see its use in clinical practice to fight the infections caused by susceptible gram-positive pathogens.