音猬因子信号通路在缺血性脑卒中不同病期中的作用

音猬因子(Shh)信号通路不仅在胚胎发育过程中发挥着举足轻重的作用,而且还参与多种病理生理过程.缺血性脑卒中的病理机制复杂,治疗手段也仅限于急性期的时间窗内.随着对Shh信号通路对缺血性脑卒中的作用的深入研究,发现该信号通路的相关基因和蛋白参与到缺血性脑卒中的各个阶段并发挥不同作用.本文综述了 Shh信号通路在缺血性脑...

Differential roles of Sonic hedgehog signaling pathway in different stages of ischemic stroke

Sonic hedgehog (Shh) signaling pathway not only plays an important role in embryo development, but also participates in many physiological and pathophysiological processes. The pathological mechanism of the occurrence and development of ischemic stroke is complex, which has not been fully understood, and the current treatment is limited to an acute time window. As the role of Shh signaling pathway in ischemic stroke being increasingly reported, it was found that genes and proteins related to the pathway may participate in various stages of ischemic stroke and play different roles.This review summarizes main findings of the role played by Shh signaling pathway in the early stage, acute stage and recovery stage of ischemic stroke. It is expected that further study of Shh signaling pathway will help to provide valuable reference to new mechanisms and drug new target for the ischemic stroke.