心脏间质细胞在心肌纤维化中的作用机制及研究进展

心肌纤维化是多种损伤因素引起的心脏间质中细胞外基质过量沉积,可导致心室顺应性下降、心肌舒缩功能障碍及心律失常的发生,与心功能不全的严重程度及不良预后密切相关.心脏间质中的成纤维细胞、内皮细胞、周细胞和免疫细胞等细胞类型因基因组学表达差异可区分为多种亚群,并通过表型转化、精细调控细胞外基质组分及分泌促纤维化或抗纤维化因子...

Mechanism and research progress of cardiac interstitial cells in myocardial fibrosiss

Myocardial fibrosis is the excessive deposition of extracellular matrix(ECM) in the cardiac interstitium caused by a variety of injury factors, which can lead to the decline of ventricular compliance, myocardial diastolic and systolic dysfunction and arrhythmia. It is closely related to the severity of cardiac insufficiency and poor prognosis. Fibroblasts, endothelial cells, pericytes and immune cells in cardiac interstitium can be divided into a variety of subgroups due to different genomic expression, and regulate myocardial fibrosis through phenotypic transformation, fine regulation of ECM components and secretion of pro-fibrosis or anti-fibrosis factors. This article reviews the role of cardiac interstitial cells in cardiac fibrosis and reveals the molecular mechanisms including signal transduction networks and epigenetic modifications, which will provide new therapeutic strategies and targets for preventing and alleviating cardiac fibrosis.