昼夜节律变化对动脉粥样硬化形成的影响及其相关通路的研究进展

地球上几乎所有的生命都存在昼夜节律,控制昼夜节律的生物钟具有重要的生理功能,同时也是疾病的重要调节器。昼夜节律与动脉粥样硬化关系密切。研究表明受损的生物钟会影响造血过程和糖脂代谢,并改变局部斑块病变中的细胞功能。在分子水平上,昼夜节律可以通过Toll样受体(TLR)通路调节动脉粥样硬化炎症状态和血管重塑,通过蛋白激酶B(Akt)通路改善内皮功能和胰岛素信号传导,并通过CCL2-CCR2信号轴影响单核细胞的招募与淋巴细胞的活化。本篇综述讨论了动脉粥样硬化中昼夜节律的作用及分子机制,以及动脉粥样硬化与生物钟系统的联系。

Research progress of circadian rhythm and related pathways in atherosclerosis

Almost all life on earth has an internal mechanism-circadian rhythm, and the circadian clock that controls the circadian rhythm has been revealed as an important regulator of physiology and disease. Circadian rhythm is closely related to atherosclerosis(As). Various studies have shown that impaired circadian clocks and disturbed sleep can affect hematopoiesis process and glucose and lipid metabolism of As,and change the cellular behavior in local plaque lesions. At the molecular level, circadian rhythm can regulate atherosclerotic inflammation and vascular remodeling through the Toll like receptor (TLR) pathway, improve endothelial function and insulin signaling through the protein kinase B (Akt) pathway, and affect the recruitment of monocytes and activation of lymphocytes through the CCL2-CCR2 signal axis.This review discussed the role and molecular mechanisms of circadian rhythm in As, in order to better understand the connection between As and the circadian clock system.