| S100A8和S100A9在冠心病中的研究进展 |
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| 引用本文： | 王润青,王永祥,张钲.S100A8和S100A9在冠心病中的研究进展[J].中国动脉硬化杂志,2021,29(7):641-644. |
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| 作者姓名： | 王润青 王永祥 张钲 |
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| 作者单位： | 兰州大学第一附属医院心脏内科,甘肃省兰州市 730000;甘肃省心血管疾病重点实验室,甘肃省兰州市 730000 |
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| 基金项目： | 甘肃省心血管疾病重点实验室建设项目(1206RTSA025) |
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| 摘 要： | S100A8和S100A9作为内源性危险相关分子模式与Toll样受体4和晚期糖基化终产物受体相识别,通过参与免疫应答,改变内皮通透性并促进斑块内炎症,从而影响动脉粥样硬化的发生和发展。此外,S100A8和S100A9血浆水平升高与增加心血管事件的风险密切相关。本文综述S100A8和S100A9的研究现状及其在冠心病的预防、治疗及预后评估中的应用前景。
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| 关 键 词： | S100A8 S100A9 动脉粥样硬化 急性冠状动脉综合征 |
| 收稿时间： | 2020/3/25 0:00:00 |
| 修稿时间： | 2020/11/17 0:00:00 |
Research progress of the relationship between S100A8 and S100A9 and coronary heart disease |
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| WANG Runqing,WANG Yongxiang,ZHANG Zheng.Research progress of the relationship between S100A8 and S100A9 and coronary heart disease[J].Chinese Journal of Arteriosclerosis,2021,29(7):641-644. |
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| Authors: | WANG Runqing WANG Yongxiang ZHANG Zheng |
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| Institution: | Department of Cardiology, First Affiliated Hospital of Lanzhou University, Lanzhou Gansu730000, China;Key Laboratory of Cardiovascular Disease, Lanzhou, Gansu 730000, China |
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| Abstract: | S100A8 and S100A9, as endogenous risk-associated molecular patterns, recognize Toll-like receptor 4 and advanced glycation end product receptors, participate in immune response, change endothelial permeability and promote inflammation within the plaque, which affects the development of atherosclerosis. In addition, the elevated plasma levels of S100A8 and S100A9 are associated with an increased risk of future cardiovascular events. This article reviews the research status of S100A8 and S100A9 and their application prospects in the prevention, treatment and prognosis evaluation with coronary heart disease. |
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| Keywords: | S100A8 S100A9 atherosclerosis acute coronary syndrome |
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