Chlorphentermine-induced lipidosislike ultrastructural alterations in testicular Leydig and Sertoli cells

Prolonged administration of the anorectic drug chlorphentermine to rats, mice, and rabbits causes the formation of abnormal cytoplasmic inclusions in Leydig and Sertoli cells. The abnormal inclusions display either concentrically lamellated patterns with a 45 Å periodicity, or a crystalloid structure. These alterations correspond to chlorphentermine-induced changes previously observed in other tissues; they are interpreted as the result of a drug-induced phospholipidosis.