Relation between Bronchial Reactivity to Antigen in Vivo and Serum IgE and IgG2a Antibody Levels in Rats |
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| Authors: | Magnus,Dahlbä ck, Romain,Pauwels, Herve,Bazin Hå kan,Bercstrand |
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| Affiliation: | Research and Development Laboratories, AB Draco, Lund, Sweden;Dept. of Respiratory Diseases, State University, Ghent;Experimental Immunology Unit, University of Louvain, Brussels, Belgium |
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| Abstract: | Sprague Dawley rats were immunized with graded doses of ovalbumin (O A) together with alum. The capacity of the animals to produce a bronchial anaphylactic response to intravenous antigen challenge was related to serum OA-IgE and OA-IgG2a antibody levels estimated by radioimmunossay. A significant correlation between bronchial anaphylactic response capacity and OA-IgE antibody levels was found under a few, but not all, of several carefully chosen experimental conditions. No correlation was demonstrable between the in vivo reactivity of the animals and their serum levels of OA-specific IgGg2a antibodies. |
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| Keywords: | bronchial anaphylaxis IgE and IgGg2a antibody levels ovalbumin sensitized SD rats |
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