Rapid Test for Fecal Calprotectin Levels in Children With Crohn Disease |
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| Authors: | Kolho Kl Turner D Veereman-Wauters G Sladek M de Ridder L Shaoul R Paerregaard A Dias J Amil Koletzko S Nuti F Bujanover Y Staiano A Bochenek K Finnby L Levine A Veres G |
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| Affiliation: | *Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland ?Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Israel ?Pediatric Gastroenterology Unit, University Hospital UZ Brussels, Belgium §Polish-American Children's Hospital, Jagiellonian University School of Medicine, Krakow, Poland ||Pediatric Gastroenterology Unit, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands ?Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel #Department of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark **Department of Pediatrics, Hospital, S. Joao, Porto, Portugal ??Dr von Haunersches Kinderspital, Ludwig Maximilians University Munich, Munich, Germany ??Department Pediatrics, La Sapienza Hospital, Rome §§Edmon & Lili Safra Children's Hospital, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel ||||Department of Pediatrics, University of Naples "Federico II," Naples, Italy ??Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw, Poland ##Unger-Vetlesens Institute, Lovisenberg Diakonale Hospital, Oslo, Norway ***Pediatric Gastroenterology Unit, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel ???1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. |
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| Abstract: | ABSTRACT: Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100?μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined. |
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