Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity |
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Authors: | Rizzo Stefano Rivière Céline Piazzi Lorna Bisi Alessandra Gobbi Silvia Bartolini Manuela Andrisano Vincenza Morroni Fabiana Tarozzi Andrea Monti Jean-Pierre Rampa Angela |
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Affiliation: | Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy. |
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Abstract: | The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl- N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect. |
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