一贯煎抗急性实验性胃溃疡和促进溃疡愈合作用

观察一贯煎胃溃疡形成与愈合的影响。方法；采用给大鼠胃饲１ｍｌ无水乙醇中０．２ＮＮａＯＨ引起急性胃溃疡的实验模型。结果；分别以６．０，１２．０和２４．０ｇ／ｋｇ的一贯煎煎剂预先胃饲大鼠，均能显著减轻无水乙醇或０．２ＮＮａＯＨ所致的包性胃粘膜损伤，且有一定的量效关系；其中对无水乙醇性胃粘膜损伤的抑制率分别为６．８％，３７．５％和９３．９％；

Yi Guan Jian Prevent the Formation and Promote Healing of Acute Experimental Gastric Ulcer

Objective: To observe the effects of Yi Guan Jian on the formation and healing of gastric ulcer. Methods: The arute experimental gastric ulcer model prepared by injecting orally 1ml the ethanol or 0.2 N NaOH into rats was used. Results: Decoction of Yi Guan Jian was administered orally in the dosage of 6.0, 12. 0 or 24.0g/kg respectively in rats, which prevented remarkably the forming of gastric mucosal damage induced by absolut ethanol or 0.2N NaOH in a dose-dependent manner(P< 0.01 or 0.001). The inhibitory rates to injury were 6.8%, 37.5% and 93.9% for absolute ethanol-induced damage respectively; 54. 8%, 68. 6% and 98.9% for 0.2N NaOH - induced one. Decoction of Yi Guan Jian(24.0g/kg/day)ana selbex(3. 0mg/kg/day)was administered orally respectively for 3 days, both of which could accelerate recovery of absolute ethanol- induced damage(P < 0.05 or 0.001). Conclusions: Yi Guan Jian can prevent the formation and promote the healing of acute gastric ulcer.