冠心病患者sCD14血清水平检测的临床意义

目的探讨血清可溶性CD14(sCD14)水平在监测冠心病病情及其与冠状动脉病变程度的关系。方法168例冠心病患者,按临床诊断分为三组:急性心肌梗死(AMI)60例、不稳定型心绞痛(UAP)58例、稳定型心绞痛(SAP)50例和对照组55例。用酶联免疫吸附试验检测各组血清sCD14的水平,并比较各组间的差异。对冠心病患者的外周血白细胞总数变化及其与血清sCD14水平进行直线相关分析。结果AMI组、UAP组及SAP组的血清sCD14水平比对照组高(P＜0．05);AMI组、UAP组sCD14水平和SAP组相比,其值增加明显;AMI组和UAP组结果相似;冠心病患者sCD14水平与外周血白细胞总数变化呈正相关。结论sCD14可能是冠状动脉粥样硬化的标志,参与了冠心病的发病过程,其值与冠状动脉病变程度密切相关。

Significance of soluble CD14 in the patients with coronary artery disease

Objective To study the relationship of soluble CD14 with the severity of coronary ar- tery disease(CAD),and to investigate whether it is a non-invasive marker of coronary plaque destabili- zation in CAD.Methods The 3 groups included 60 cases of acute myocardial infarction(AMI group) within 14 hours after the onset,58 cases of unstable angina pectoris(UAP group)within 14 hours after the last episode,50 cases of stable angina pectoris(SAP group),and the control group consisted of 55 cases. Serum level of soluble CD14 was measured by enzyme-linked immunosorbent assay(ELISA).The differ- ences of soluble CD14 levels between different groups were observed.Linear correlation analysis was used to analyze the relationship between the level of soluble CD14 and white blood cell(WBC)in CAD patients. Results Compared with the control group,the levels of soluble CD14 were higher in AMI,UAP and SAP groups.Compared with SAP group,the levels of soluble CD14 were elevated obviously in AMI and UAP groups,while there were no significant differences between AMI group and UAP group.The levels of solu- ble CD14 were correlated with a total of peripheral WBC in CAD patiems.Conclusion Soluble CD14 can be used as a marker of the presence of coronary atherosclerosis and is involved in the pathogenesis of CAD.The levels of soluble CD14 were correlated with the severity of CAD.