| Effect of Tiaoxin Recipe(调心方)on Spatial Memory and Energy Metabolism of Oxidation Injured Alzheimer's Disease Rats |
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| 作者姓名： | 邱宏 金国琴 赵伟康 张学礼 |
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| 作者单位： | Institute of Basic Medicine,Shanghai University of TCM,Shanghai 200032,Institute of Basic Medicine,Shanghai University of TCM,Shanghai 200032,The Research Institute of Gerontology of Shanghai TCM,Institute of Basic Medicine,Shanghai University of TCM,Shanghai 200032 |
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| 基金项目： | This program was supported by National Natural Science Foundation of China (No. 39830450) |
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| 摘 要： | Objective: To observe the effect of Tiaoxin Recipe (TXR) on the spatial memory, brain mitochondrial energy metabolism of oxidation injured Alzheimer's disease (AD) rats, and to explore the mechanism of TXR in treating AD. Methods: Eighty-eight SD rats were randomly divided into five groups (normal group, operative group, "AD" model group,TXR group and Aricept group). An oxygen free radical generation system (dihydroxy fumaric acid-trichloroferric-adenosine diphosphate, DHF-FeCl3-ADP) was used to create oxidation injured rat models mimic to AD; spatial learning and memory impairment (Morris water maze method), the activity of Succinate-oxidase, NADH-oxidase, CytC-oxidase (Clark oxygen electrode method) and the expression of cytochrome oxidase (CO) II mRNA (in situ hybridization method) were observed. Results: Compared with the normal group, the spatial memory, activity of CytC-oxidase and COII mRNA expression of oxidation injured "AD" rats were obviously decreased; TXR, however, could improve these funct
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