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| CD44v6和E-上皮钙黏附素在前列腺癌组织中的表达与癌转移的关系 | |
| 引用本文： | 谷化平,尚培中,周翠玲.CD44v6和E-上皮钙黏附素在前列腺癌组织中的表达与癌转移的关系[J].中华男科学杂志,2004,10(1):32-34,38. |
| 作者姓名： | 谷化平 尚培中 周翠玲 |
| 作者单位： | 1. 解放军第251医院病理科,河北,张家口,075000 2. 解放军第251医院普外科,河北,张家口,075000 3. 张家口医学院第一附属医院普外科,河北,张家口,075000 |
| 摘 要： | 目的 :探讨CD4 4v6和E 上皮钙黏附素 (E cadherin ,ED)表达与前列腺癌转移的关系。 方法 :应用免疫组化方法 ,对 4 5例前列腺癌组织进行了CD4 4v6和ED蛋白检测。 结果 :在前列腺癌中CD4 4v6和ED表达阳性率为77.8%和 4 8.9%。CD4 4v6高表达和ED低表达与前列腺癌分化程度、临床病理分期和转移密切相关 (P <0 .0 5 )。CD4 4v6表达与ED表达呈负相关 (r=0 .5 8,P <0 .0 0 5 )。 结论 :CD4 4v6和ED蛋白表达可作为辅助临床判断前列腺癌生物学行为和预测预后的参考指标 |
| 关 键 词： | 前列腺肿瘤 癌 CD44v6 E-上皮钙黏附素 免疫组织化学 |
| 文章编号： | 1009-3591(2004)01-0032-04 |
| 修稿时间： | 2002年11月25 |
Expression of CD44v6 and E-cadherin in Prostate Carcinoma and Metastasis of Prostate Carcinoma |
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| Gu Huaping,Shang Peizhong,Zhou Cuiling.Expression of CD44v6 and E-cadherin in Prostate Carcinoma and Metastasis of Prostate Carcinoma[J].National Journal of Andrology,2004,10(1):32-34,38. | |
| Authors: | Gu Huaping Shang Peizhong Zhou Cuiling |
| Institution: | Department of Pathology, 251st Hospital of PLA, Zhangjiakou, Hebei 075000, China. guhuapingzjk@sohu.com |
| Abstract: | Objective: To study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma. Methods: The expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique. Results: The positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%,respectively.The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P< 0.05).The expression of CD44v6 was negatively correlated with ED(r=- 0.58, P< 0.005). Conclusions: The expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor. |
| Keywords: | CD44v6 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |