| 蒙脱石散对氧氟沙星体外吸附作用研究 |
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| 引用本文： | 吴骏,李刚,于永洲,徐江红,肖汉扬.蒙脱石散对氧氟沙星体外吸附作用研究[J].中国药房,2005,16(19):1461-1462. |
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| 作者姓名： | 吴骏 李刚 于永洲 徐江红 肖汉扬 |
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| 作者单位： | 解放军第94医院 南昌市330002
(吴骏，李刚，于永洲，徐江红)，解放军第94医院 南昌市330002(肖汉扬) |
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| 摘 要： | 目的:研究蒙脱石散对氧氟沙星的体外吸附作用。方法:取不同剂量的氧氟沙星与蒙脱石散分别混合于人工胃液和人工肠液中,(37±0.5)℃水浴恒温1h后过滤,采用紫外分光光度法测定氧氟沙星的含量变化。结果:在人工胃液和人工肠液中,蒙脱石散对氧氟沙星的吸附率分别为(99.76±0.01)%和(99.55±0.02)%。结论:蒙脱石散在人工胃液和人工肠液中对氧氟沙星有强大的吸附作用,应避免同时服用2药。
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| 关 键 词： | 蒙脱石散 氧氟沙星 吸附 人工胃液 人工肠液 |
| 文章编号： | 1001-0408（2005）19-1461-02 |
| 收稿时间： | 2005-03-03 |
| 修稿时间： | 2005-05-08 |
Study on the Ex Vivo Adsorption of Montmorillonite Powder to Ofloxacin |
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| WU Jun,LI Gang,YU Yongzhou,XU Jianghong,XIAO Hanyang.Study on the Ex Vivo Adsorption of Montmorillonite Powder to Ofloxacin[J].China Pharmacy,2005,16(19):1461-1462. |
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| Authors: | WU Jun LI Gang YU Yongzhou XU Jianghong XIAO Hanyang |
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| Abstract: | OBJECTIVE:To study the ex vivo adsorption of montmorillonite powder to ofloxacin.METHODS:Different dosages of ofloxacin and montmorillonite powder were mixed with artificial gastric juice and artificial intestinal juice,respecˉtively,which were filtrated after warmed at(37±0.5)℃in water bath for1hour,the content changes of ofloxacin were deˉtermined by ultraviolet spectrometry.RESULTS:The adsorption rates of montmorillonite powder to ofloxacin in artificial gastric juice and in artificial intestinal juice were(99.76±0.01)%and(99.55±0.02)%,respectively.CONCLUSIONS:Montmorillonite powder has strong adsorption to ofloxacin in both artificial gastric juice and artificial intestinal juice,thereˉfore,which should not be administered simultaneously in the clinic. |
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| Keywords: | Montmorillonite powder Ofloxacin Adsorption Artificial gastric juice Artificial intestinal juice |
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