| 30例老年性痴呆患者脑CT与P300的相关性研究 |
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| 引用本文： | 张莉莉,王景周. 30例老年性痴呆患者脑CT与P300的相关性研究[J]. 第三军医大学学报, 2004, 26(17): 1533-1535 |
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| 作者姓名： | 张莉莉 王景周 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所神经内科,重庆,400042;第三军医大学大坪医院野战外科研究所神经内科,重庆,400042 |
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| 摘 要： | 目的观察老年性痴呆患者脑CT与听觉认知电位P300的变化,探讨对老年性痴呆进行综合评价的有效方法.方法采用脑CT和听觉认知电位P300检查,结合神经心理学测试,对30例老年性痴呆患者进行测试.结果听觉认知电位检查发现患者的P300潜伏期明显延长,波幅显著降低;CT测量外侧裂宽度和额角指数明显升高,反映了以额颞叶为主的脑萎缩.诱发电位和脑CT检查结果均与患者的痴呆程度呈显著性相关.结论利用脑CT和听觉认知电位P300,结合简易精神状态检查(MMSE)量表,可从形态、功能和神经心理学角度对老年性痴呆患者作出确切评价,是早期发现老年性痴呆病人的有效手段.
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| 关 键 词： | 老年性痴呆 脑CT 听觉认知电位P300 |
| 文章编号： | 1000-5404(2004)17-1533-03 |
| 修稿时间： | 2003-10-16 |
Study of the correlation of cerebral CT and P300 in 30 patients with Alzheimer's disease |
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| ZHANG Li li,WANG Jing zhou. Study of the correlation of cerebral CT and P300 in 30 patients with Alzheimer's disease[J]. Acta Academiae Medicinae Militaris Tertiae, 2004, 26(17): 1533-1535 |
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| Authors: | ZHANG Li li WANG Jing zhou |
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| Abstract: | Objective To observe the changes of cerebral CT and auditory event related potentials (ERP, P300) for finding the effective method for the comprehensive evaluation of the patients with Alzheimer's disease. Methods Cerebral CT, P300, and Mini Mental State Examination (MMSE) were employed to assess 30 patients with Alzheimer's disease. Results Latency and amplitude of wave of P300 in patients were prolonged and decreased, respectively. Cerebral CT found an obvious atrophy in the frontal and temporal lobes of cerebra. These changes were obviously correlated with the severity of dementia. Conclusion Using cerebral CT, P300, and MMSE can offer morphometric, functional and psychological information which is helpful for precise assessment of patients with Alzheimer's disease. |
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| Keywords: | Alzheimer's disease cerebral CT P300 |
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