| 麻杏石甘滴丸与栓剂体外溶出度比较 |
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| 引用本文： | 何群,曾嵘,王丽,黄佑. 麻杏石甘滴丸与栓剂体外溶出度比较[J]. 中成药, 2000, 22(12): 833-835 |
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| 作者姓名： | 何群 曾嵘 王丽 黄佑 |
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| 作者单位： | 湖南中医学院药学院,湖南,长沙,410004 |
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| 摘 要： | 目的：探讨麻杏石甘滴丸与栓剂的体外释药规律。方法：采用转篮法测定两者的体外溶出度，用酸性染料比色法测定制剂中麻黄总生物碱的含量并以此作为溶出指标。结果：滴丸的４５ｍｉｎ内溶出量达１００％。栓剂的４５ｍｉｎ内溶出量达９２．５８％。结论：两者的Ｔ５０，Ｔｄ有显著性差异（Ｐ〈０．０５），滴丸溶出快于栓剂。
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| 关 键 词： | 麻杏石甘 滴丸 体外溶出度 栓剂 中药 |
| 文章编号： | 1001-1528(2000)12-0833-03 |
| 修稿时间： | 2000-09-03 |
Comparison of Dissolution Rates in vitro of Maxingshigan Dropping Pill and Suppository |
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| HE Qun,ZENG Rong,WANG Li,HUANG You. Comparison of Dissolution Rates in vitro of Maxingshigan Dropping Pill and Suppository[J]. Chinese Traditional Patent Medicine, 2000, 22(12): 833-835 |
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| Authors: | HE Qun ZENG Rong WANG Li HUANG You |
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| Abstract: | Objective: To explorate the drug releasing rule in vitro of Maxingshigan Dropping pill and Suppository. Methods: Their dissolution rates in vitro were determined by the rotary basket method, the contents of total alkaloid in ephedra alkaloid in the two preparations were determined by acidic dye colorimetry, and they were used as markers of dissolution.Results:The dissolution quantity in 45 min of Dropping pill reached 100%, whereas that of suppository reached 92.58%. Conclusion: T 50 , T d of the two preparations showed significant difference ( P <0.05). The dissolution rate of dropping pill was faster than that of suppository. |
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| Keywords: | Maxingshigan Dropping pill Maxingshigan Suppository dissolution rate in vitro rotary basket method Ephedra alkaloid acidic dye colorimetry |
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