术后镇痛对初乳sIgA的影响

目的：探讨剖宫产及剖宫产术后硬膜外镇痛对母体初乳中分泌型免疫球蛋白A（sIgA）含量的影响。方法：顺产（NL）、剖宫产（CS）及剖宫产术后使用镇痛（CS-A）的初产妇各10例，记录分娩后首次产生初乳的时间，测定首次初乳和随后24h、48h初乳中sIgA含量。结果：产生首次初乳的时间顺序为CS组〉CS-A组〉NL组（P〈0．05）；初乳中sIgA值：首次初乳NL组〉CS-A组〉CS组（P〈0．05）；初乳24hCS组〈NL组、CS-A组（P〈0．05）；初乳48h三组含量无差异（P〉0．05）。结论：剖宫产延迟初产妇的初乳产生、减少初乳中sIgA含量，术后使用镇痛可改善这种影响。

THE EFFECTS OF ANALGESIA AFTER CESAREAN SECTION ON THE CONCENTRATION OF sIgA IN HUMAN COLOSTRUM

Objective: To study the effects of analgesia after cesarean section on the concentration of sIgA in human colostrum.Methods: The times of the first colostrum production were recorded and the sIgA content in the first colostrum,24 h and 48 h colostrum were determined in 30 cases primipara of normal labor(NL) and cesarean section(CS) and analgesia after cesarean section(CS-A).Results: The order of time in the first colostrum production were CS group > CS-A group >NL group(P<0.05).The sIgA contents of colostrum were NL group > CS-A group >CS group(P<0.05).Those in 24 h colostrum in CS group was significantly less than NL group and CS-A group(P<0.05).There was no significant difference of those in 24 h colosfrum among three groups(P>0.05).Conclusion: The cesarean section could delay the production of human colostrum and reduce the sIgA content in human colostrum in primipara,but they could be improved by analgesia after cesarean section.