复发性生殖器疱疹患者黏附分子ICAM-1、L-选择素和P-选择素的表达

目的 探讨ICAM－1、L－选择素及P－选择素在复发性生殖器疱疹（RGH）患者发作期和静止期的变化规律及相关性。方法 用免疫荧光染色法及流式细胞术分析了19例发作期和16例静止期RGH患者外周血黏附分子ICAM－1，L－选择素及P－选择素表达情况。结果 RGH患者发作期外周血淋巴细胞ICAM－1表达显著高于RGH静止期患者及正常对照组（P＜0．01），淋巴细胞表达的L－选择素及血小板表达的P－选择素在RGH患者发作期、静止期及正常对照组之间差异无显著性（P＞0．05），外周血淋巴细胞ICAM－1的表达与RGH患者年复发次数有明显的相关性（P＜0．05）。结论 RGH患者外周血淋巴细胞ICAM－1的表达水平可作为判断RGH复发及病情严重程度的参考指标。

Expression of adhesion molecules in patients with recurrent genital herpes

Objective To study the expression of ICAM-1,L-selectin and P-selectin in lymphocytes and platelets from patient with recurrent genital herpes (RGH). Methods Adhseion molecules ICAM-1,L-selectin and P-selectin were investigated in 19 active RGH and 16 in inactive RGH patients by using flow cytometric analysis and immunofluorescence staining method. Results Expression of ICAM-1 in lymphocytes from active stage RGH was significant higher than that of inactive RGH and control ( P < 0.01 ). Expression of L-selectin in lymphocytes and P-selectin in platelets from active stage and inactive stage RGH patients were not significantly different compared with normal control( P >0.05). In addition , the recurrence times of RGH were significantly correlated with expression ICAM-1 in RGH patient ( P < 0.05 ). Conclusion Expression of ICAM-1 in lymphocytes from active RGH increases. It is important to have further study on the pathogenic significance of ICAM-1 in RGH.