| 芒黄颗粒对糖尿病肾病大鼠的保护作用 |
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| 引用本文： | 王建玮,卢晗滢,林贺,律广富,张靖卓,常志达,林喆.芒黄颗粒对糖尿病肾病大鼠的保护作用[J].长春中医药大学学报,2015(6). |
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| 作者姓名： | 王建玮 卢晗滢 林贺 律广富 张靖卓 常志达 林喆 |
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| 作者单位： | 1. 长春中医药大学,长春,130117;2. 长春市妇产医院,长春,130022 |
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| 摘 要： | 目的：探讨芒黄颗粒（MHG）对Ⅱ型糖尿病肾病大鼠动物模型的保护作用。方法以腹腔注射链脲佐菌素（STZ）并长期高脂饮食制备大鼠糖尿病肾病模型。对大鼠血清空腹血糖（FBG）、空腹胰岛素（FINS）、血脂、肌酐（SCr）、尿素氮（BUN）、24 h 尿微量蛋白的含量等进行测定。结果 MHG 可显著降低造模大鼠空腹血糖、空腹胰岛素含量以及胰岛素抵抗指数，可显著降低造模大鼠血清三酰甘油、胆固醇、高密度脂蛋白及游离脂肪酸含量，能够显著降低模型大鼠 SCr、BUN 及尿微量蛋白含量。结论芒黄颗粒对糖尿病肾病大鼠具有较好的保护作用。
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| 关 键 词： | 芒黄颗粒 糖尿病肾病 血糖 胰岛素 |
Mangiferin hydrastis granulein in rats with diabetes nephropathy mellitus |
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| Abstract: | objective To explore the protective effects of mangiferin hydrastis granulein in rats with diabetes nephrop-athy mellitus. Methods By intraperitoneal injection of STZ and long-term high fat diet preparation in the rat model of diabetic nephropathy. To test the fasting blood glucose(FBG),fasting insulin(FINS),blood lipid,creatinine (SCr),urea nitrogen(BUN)and 24 h urine micro protein content etc of rat serum. Results MHG can reduce the rats fasting glucose,fasting insulin levels and insulin resistance index significantly. It also can reduce the rats serum triglyceride,cholesterol,high-density lipoprotein cholesterol and free fatty acid content conspicuously. In addition, MHG can decrease significantly to the model rats SCr,BUN,urinary trace protein content. Conclusion Mangiferin hydrastis granulein can protect the diabetic nephropathy rats. |
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| Keywords: | Mangiferin hydrastis granulein diabetic nephropathy blood glucose insulin |
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