Telomerase-specific GV1001 peptide vaccination fails to induce objective tumor response in patients with cutaneous T cell lymphoma |
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Authors: | Schlapbach Christoph Yerly Daniel Daubner Barbara Yawalkar Nikhil Hunger Robert E |
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Affiliation: | a Department of Dermatology, Inselspital, University of Bern, 3010 Bern, Switzerland;b Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology Inselspital, University of Bern, Bern, Switzerland |
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Abstract: | BackgroundThere is currently no curative therapy for cutaneous T cell lymphoma (CTCL). New therapies are therefore needed. Telomerase, the enzyme that allows for unrestricted cell divisions of cancer cells, is a promising target for cancer therapy. The telomerase-specific peptide vaccination GV1001 has shown promising results in previous studies. Since telomerase is expressed in malignant cells of CTCL, GV1001 vaccination in CTCL is a promising new therapeutic approach.ObjectiveWe sought to investigate the efficacy of GV1001 vaccination in CTCL patients and characterize the induced immune response.MethodsSix CTCL patients were vaccinated with the GV-peptide using granulocyte/macrophage colony-stimulating factor as adjuvant. Objective clinical response and the T cell response were assessed.ResultsNone of the patients demonstrated objective clinical response to the vaccination whereas one patient showed disease progression. 1/6 patients acquired a GV1001-specifc T cell response with a Th1 cytokine profile and expression of skin-homing receptors. This hTERT-specific T cell response was not associated with beneficial modulation of the tumor-infiltrating leukocytes. Furthermore, removal of regulatory T cells did not enhance responsiveness to GV1001 in vitro in any of the patients analyzed.ConclusionsOur results suggest that the GV1001 vaccination is not effective in CTCL patients and disease progression in 1/6 patients raises concerns about its safety. By analyzing skin-homing properties of GV1001-specific T cells and the involvement of regulatory T cells we nevertheless provide insight into vaccine-induced immune responses which may help to improve vaccine strategies in CTCL. |
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Keywords: | Cutaneous T cell lymphoma (CTCL) GV1001 Tumor vaccination Telomerase hTERT-specific peptide vaccination Regulatory T cells (Treg) Skin-homing receptors CCR4 CCR6 Granulocyte-monocyte colony stimulating factor (GM-CSF) |
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