| 盐酸莫雷西嗪的合成 |
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| 引用本文： | 王绍杰,郝东,陈欣,杨卓.盐酸莫雷西嗪的合成[J].中国新药杂志,2006,15(14):1188-1190. |
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| 作者姓名： | 王绍杰 郝东 陈欣 杨卓 |
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| 作者单位： | 沈阳药科大学制药工程学院,沈阳,110016 |
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| 摘 要： | 目的：合成抗心律失常药盐酸莫雷西嗪。方法：以3-溴硝基苯、乙酰苯胺为原料经烃化、水解反应得3-硝基二苯胺，经硫化亚铁-氯化铵-甲醇-水体系还原得3-氨基二苯胺，再经酰化、环合、烃化和成盐反应得盐酸莫雷西嗪。结果：合成了盐酸莫雷西嗪，9步反应总收率为35．8％。目标产物的结构经核磁共振氢谱、质谱确证。结论：本合成方法原料易得，操作简单，收率较高，适合大规模制备。
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| 关 键 词： | 盐酸莫雷西嗪 药物合成 抗心律失常 |
| 文章编号： | 1003-3734（2006）14-1188-03 |
| 修稿时间： | 2005-12-23 |
Synthesis of moracizine hydrochloride |
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| WANG Shao-jie,HAO Dong,CHEN Xin,YANG Zhuo.Synthesis of moracizine hydrochloride[J].Chinese Journal of New Drugs,2006,15(14):1188-1190. |
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| Authors: | WANG Shao-jie HAO Dong CHEN Xin YANG Zhuo |
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| Institution: | College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016,China |
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| Abstract: | Objective:To synthesize antiarrythmic drug moracizine hydrochloride.Methods: Starting from 3-bromonitrobenzene and acetanilide,the intermediate 3-nitrodiphenylamine was obtained via alkylation and hydrolysis.Subsequently,the target compound was synthesized via several chemical re- actions including reduction,acylation,cyclization,alkylation and saltization.Results:The total yield of moracizine hydrochloride was 35.8%,and the structure was verified by ~1H-NMR and MS.Conclusion:An easily manipulated synthetic procedure of moracizine hydrochloride was achieved for further pilot manufacture. |
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| Keywords: | moracizine hydrochloride synthesis antiarrythmia |
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