冠心病与ACE基因多态性的相关性研究

为研究血管紧张素转移酶（angiotensin coverting enzyme,ACE)基因插入/缺失（insertion/deletion,I/D)多态性与冠心病（coronary artery disease,CAD)的相关性，我们对105例CAD患者{其中50例合并原发性高血压（essential hypertension,EH）}和102例正常人以多聚酶链反应（polymerase chain reaction,PCR)方法检测其ACE基因多态性。发现CAD组（含合并EH）与正常对照组比较，ACE基因型无显著差异，CAD组（不含合并EH）与CAD组（合并EH）比较，ACE基因型无显著差异，CAD组（不含合并EH）或CAD组（合并EH）分别与正常对照组比较，ACE基因型也无显著差异。提示ACE基因I/D多态性与CAD及CAD合并EH均无相关性。

Relation Between Coronary Artery Disease and Polymorphism of Angiotensin Converting Enzyme Gene

This study was aimed to determine the relationship between coronary artery disease(CAD) and insertion/deletion(I/D) polymorphism of the angiotensin coverting enzyme(ACE) gene.The ACE genotypes of 105 patients with CAD (50 of them were accompanied by essential hypertension (EH) ) and 102 healthy people were detected by polymerase chain reaction.The results showed that in terms of ACE genotypes, no significant difference was noted between CAD group and control group,nor was it observed between CAD group and CAD accompanied by EH group, and nor was it seen between CAD/CAD accompanied by EH group and control group.These findings suggest that there is no relationship between the polymorphism of ACE gene and CAD (including those accompanied by EH).