Locomotion elicited by lateral hypothalamic stimulation in the anesthetized rat does not require the dorsal midbrain |
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| Authors: | H M Sinnamon C K Stopford |
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| Institution: | 1. Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, United States;2. Laboratory of Endocrine and Neuropsychiatric Disorders, Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, United States;1. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States;2. Department of Pathology, Flow Cytometry Core, Massachusetts General Hospital, Boston, MA, United States;3. Scintillon Institute, La Jolla, CA, United States;4. Flow Cytometry Core, Beth Israel Deaconess Medical Center, Boston, MA, United States;5. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States |
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| Abstract: | Locomotor stepping elicited by lateral hypothalamic stimulation in the anesthetized rat is blocked by lesions in the anterior ventromedial midbrain. This study determined in acute experiments whether the dorsal midbrain regions implicated in locomotion were also part of the necessary pathway. Rats were anesthetized with Nembutal and held in a stereotaxic apparatus so that stepping responses rotated a wheel. Stepping was elicited by stimulation of the lateral hypothalamus (up to 100 microA, 0.5 ms cathodal pulses, 50 Hz, 10-s train length). Nine rats received unilateral lesions ipsilateral to the locomotor electrode and 3 rats received bilateral lesions. None of the dorsal midbrain lesions reduced locomotion elicited by ipsilateral lateral hypothalamic stimulation. Therefore the following regions are unnecessary for this type of locomotion: the dorsal and lateral central gray, the tegmentum lateral to the central gray, and in particular the area cuneiformis and the dorsal aspect of the pedunculopontine region. The neural systems required for lateral hypothalamic locomotion are located ventral to the superior cerebellar peduncle. |
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