| 降纤酶对缺血再灌注后大鼠脑梗死体积的影响 |
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| 引用本文： | 白蓉,晁志文,董瑞鸿,张博爱.降纤酶对缺血再灌注后大鼠脑梗死体积的影响[J].郑州大学学报(医学版),2004,39(4):659-660. |
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| 作者姓名： | 白蓉 晁志文 董瑞鸿 张博爱 |
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| 作者单位： | 郑州铁路局中心医院神经内科,郑州,450052;郑州大学第一附属医院神经内科,郑州,450052 |
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| 摘 要： | 目的 :观察降纤酶对大鼠缺血再灌注脑梗死体积的影响。方法 :采用大鼠脑缺血再灌注动物模型 ,观察大鼠脑缺血 3h ,再灌注 3h、6h、2 4h及脑缺血 6h ,再灌注 3h、6h、2 4h降纤酶对大鼠脑缺血再灌注脑梗死体积的影响。各组均设生理盐水对照组。结果 :与生理盐水组比较 ,降纤酶组在缺血 3h再灌注 6h、2 4h ,脑梗死体积比减小(P <0 .0 5 ) ,在缺血 3h再灌注 3h和缺血 6h再灌注 3h、6h、2 4h ,脑梗死体积比与生理盐水组比较无明显变化 (P >0 .0 5 )。结论 :在缺血 3h时间窗内 ,降纤酶能够减小缺血再灌注后大鼠脑梗死体积 ,对脑组织具有一定的保护作用
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| 关 键 词： | 降纤酶 脑梗死体积 缺血 再灌注 大鼠 |
| 修稿时间： | 2003年11月10 |
Influence of defibrase on the cerebral infaction volume of brain ischemia reperfusion in rats |
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| BAI Rong ,CHAO Zhiwen ,DONG Ruihong ,ZHANG Boai.Influence of defibrase on the cerebral infaction volume of brain ischemia reperfusion in rats[J].Journal of Zhengzhou University: Med Sci,2004,39(4):659-660. |
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| Authors: | BAI Rong CHAO Zhiwen DONG Ruihong ZHANG Boai |
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| Institution: | BAI Rong 1),CHAO Zhiwen 1),DONG Ruihong 1),ZHANG Boai 2) 1) Department of Neurology,the Center Hospital of Zhengzhou Railway Station,Zhengzhou 450052 2)Department of Neurology,the first Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To observe the influence of defibrase on the cerebral infaction volume of brain ischemia reperfusion in rats. Methods: Using the model of rat ischemra reperfusion, the influence of the cerebral infaction volume at various time points after defibrase treatment were observed. Results: The infaction volume significantly decreaced in fibrinolytic groups when reperfusing 6 h and 24 h after ischemra 3 h compared with the saline control group.While there was no significant difference between the defibrase groups and the saline control group when reperfusion 3 h after ischemra 3 h and reperfusion 3 h,6 h and 24 h after ischemia 6 h . Conclusion: The defibrase can decreace the cerebral ischemra volume, expend therapeutic window of brain infarction and have protective effect on the brain tissue. |
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| Keywords: | defibrase cerebra infaction volume ischemia reperfusion rat |
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