伊维菌素和阿苯达唑伍用治疗钩虫、鞭虫感染的疗效观察

目的　观察伊维菌素和阿苯达唑伍用驱治钩虫和鞭虫感染的疗效。　方法　用伊维菌素 6mg和 12mg分别伍用阿苯达唑 2 0 0mg顿服治疗钩虫感染者 ,伊维菌素 12mg伍用阿苯达唑 2 0 0mg顿服治疗鞭虫感染者 ;同时 ,用阿苯达唑40 0mg顿服分别治疗钩虫和鞭虫感染者。用虫卵阴转率评价疗效。　结果　 6mg和 12mg伊维菌素伍用阿苯达唑治疗钩虫感染者 ,其虫卵阴转率分别为 93 .3 %和 95 .5 % ,12mg伊维菌素伍用阿苯达唑治疗鞭虫感染者 ,其虫卵阴转率为 94.3 % ;而单用阿苯达唑治疗钩虫和鞭虫感染者 ,其虫卵阴转率分别为 66.7%和 47.1%。　结论　伊维菌素和阿苯达唑伍用驱治钩虫和鞭虫感染的效果良好 ,两药有协同作用 ,而不良反应轻微、短暂。

OBSERVATION ON THE CURATIVE EFFECTS OF IVERMECTIN COMBINED WITH ALBENDAZOLE AGAINST HOOKWORM AND WHIPWORM

Objective To observe the curative effects of ivermectin combined with albendazole against hookworm and whipworm. Methods The villagers whose stool examination for hookworm eggs was positive were treated with a single oral dose of 6 mg or 12 mg ivermectin combined with 200 mg albendazole. The villagers whose stool examination for whipworm eggs was positive were treated with a single oral dose of 12 mg ivermectin combined with 200 mg albendazole;and the villagers whose stool examination for hookworm or whipworm eggs was positive were treated with a single oral dose of 400 mg albendazole. The egg reversions were evaluated. Results 6 mg or 12 mg ivermectin combined with 200 mg albendazole was used to treat the villagers infected with hookworm,the egg reversion rate was 93.3% and 95.5% respectively. 12 mg ivermectin combined with 200 mg albendazole was used to treat the villagers infected with whipworm,the egg reversion rare was 94.3%. While a single dose of 400 mg albendazole was used to treat the villagers infected with hookworm or whipworm,the egg reversion rate was 66.7% and 47.1% respectively. Conclusion Ivermectin combined with albendazole has high curative effects against hookworm and whipworm with mild and transient side effects.