不同促排卵方案治疗多囊卵巢综合征并不孕症临床研究

目的 探讨不同促排卵方案治疗多囊卵巢综合征(PCOS)并不孕症的临床疗效.方法 选取南通大学附属海安医院2016年10月至2019年6月收治的PCOS并不孕症患者135例,随机分为3组,各45例.观察组患者予枸橼酸氯米芬片、来曲唑片、注射用尿促性素和注射用绒促性素治疗;对照1组患者不予来曲唑片、对照2组患者不予枸橼酸氯...

Clinical Study of Different Ovulation Induction Schemes in the Treatment of Patients with Polycystic Ovary Syndrome Complicated with Infertility

Objective To investigate the clinical efficacy of different ovulation induction schemes in the treatment of patients with polycystic ovary syndrome(PCOS)complicated with infertility.Methods A total of 135 patients with PCOS complicated with infertility admitted to the Hai’an Hospital Affiliated to Nantong University from October 2016 to June 2019 were selected and randomly divided into three groups,45 cases in each group.The patients in the observation group were treated with Clomiphene Citrate Tablets,Letrozole Tablets,Urotropin for Injection and Chorionic Gonadotropin for Injection,the patients in the control groupⅠreceived the same therapy as the treatment group without taking Letrozole Tablets,the patients in the control groupⅡreceived the same therapy as the treatment group without taking Clomiphene Citrate Tablets.Results At the end of the first treatment cycle,compared with those in the two control groups,the estradiol(E2)level,endometrial thickness,cervical mucus score and clinical pregnancy rate in the observation group were significantly higher,the number of mature follicles in the observation group was significantly more,the diameter of the largest follicle in the observation group was significantly longer,while the testosterone(T)level,the luteinizing hormone/follicle-stimulating hormone(LH/FSH)value,the incidence of ovarian hyperstimulation syndrome(OHSS)and the early abortion rate in the observation group were significantly lower(P<0.05).The incidence of adverse reactions in the three groups was similar(P<0.05).Conclusion Clomiphene citrate combined with letrozole can regulate the sex hormone level of patients with PCOS complicated with infertility,improve ovulation induction effect and pregnancy outcome.