Congenital anomalies,labor/delivery complications,maternal risk factors and their relationship with perfluorooctanoic acid (PFOA)-contaminated public drinking water |
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| Authors: | Lynda A. Nolan John M. Nolan Frances S. Shofer Nancy V. Rodway Edward A. Emmett |
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| Affiliation: | 1. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States;2. Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States;3. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States;4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States;5. Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, United States;6. Department of Pediatrics, Children''s Hospital of Los Angeles, The Saban Research Institute, United States;1. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;4. Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain;5. Subdirección de Salud Pública y Adicciones de Gipuzkoa, Donostia-San Sebastián, Spain;6. Instituto de Investigación Sanitaria BIODONOSTIA, Donostia-San Sebastián, Spain;7. Facultad de Psicología, Universidad del País Vasco (UPV/EHU), Donostia-San Sebastián, Spain;8. Institute for Occupational Medicine, RWTH Aachen University, Aachen, Germany;1. Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403 Oslo, Norway;2. The University of Texas Health Science Center at Houston School of Public Health, San Antonio Regional Campus, San Antonio, TX 78229, USA;3. Statistics Norway, P.O. Box 8131, Dep, N-0033 Oslo, Norway;4. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA;5. Division of Epidemiology, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403 Oslo, Norway |
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| Abstract: | BackgroundWe have previously examined the associations between perfluorooctanoic acid (PFOA) exposure, birth weight and gestational age in individuals exposed to PFOA-contaminated residential drinking water from the Little Hocking Water Association (LHWA). In this investigation, we expand the scope of our analysis to examine the associations between PFOA, congenital anomalies, labor and delivery complications and maternal risk factors.ObjectivesTo compare the likelihood of congenital anomalies, labor and delivery complications and maternal risk factors in neonates and their mothers residing in zip codes with public water service provided completely, partially or not at all by the LHWA.MethodsLogistic regression analyses were performed on singleton neonatal birth outcome data supplied by the Ohio Department of Health to examine the associations between LHWA water service category and the outcomes of interest. When possible, models were adjusted for maternal age, preterm birth, neonatal sex, race, maternal education, alcohol use, tobacco use and diabetic status.ResultsIncreased PFOA exposure, as assessed by water service category, was not associated with an overall increase in the likelihood of congenital anomalies or any specific diagnosis (adjusted OR: 1.4, 95% CI: 0.34–3.3). The overall likelihood of labor and delivery complications was significantly lower among mothers with water service provided by the LHWA, as compared to mothers not serviced by the LHWA (adjusted OR: 0.65, 95% CI: 0.46–0.92). A significant increase in the likelihood of anemia (crude OR: 11, 95% CI: 1.8–64) and dysfunctional labor (crude OR: 5.3, 95% CI: 1.2–24) was noted for mothers residing within zip codes serviced by the LHWA, but the number of reported cases was very small.ConclusionAt the levels measured in the LHWA, we conclude that PFOA is not associated with increased risk of congenital anomalies, most labor and delivery complications and maternal risk factors. Additional research is required to assess the observed associations between PFOA, anemia and dysfunctional labor. |
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