前列腺素E1对慢性乙型肝炎肝功能和肝纤维化指标的影响

本文应用前列腺素E1治疗慢性乙肝患者28例，分别于治疗前和治疗结束时抽血查血清谷丙转氨酶（GPT），血清总胆红素（TBIL），血清总胆汁酸（TBA），透明质酸（HA）和前Ⅲ型胶原（PCⅢ），治疗1个月后，观察组GP，TBIL，TBA，HA及PCⅢ治疗前后相比差异具有显著性（P＜0．05），和对照组相比差异也具有显著性（P＜0．05），提示PGE1能明显改善慢性乙肝患者肝功能，并具有一定的抗肝纤维化作用。

Effects of prostaglandin E1 on hepatic function and hepatofibrosis in patients with chronic hepatitis B]

To search for an effective drug to cure patients with chronic hepatitis B. Twenty eight patients with chronic hepatitis B were treated with prostaglandin E1. The comprehensive indexes, including glutamic pyruric tranasaminase (GPT), serum total bilirubin (TBIL), total bile acid (TBA), hyaluronic acid (HA) and precollagen type III (PCIII), were examined before and after treatment. The levels of GPT, TBIL, TBA, HA, PCIII after 1 month of the treatment were significantly lower than those before the treatment (P < 0.05), there were significant differences between the treated and the controlled group patients with chronic hepatitis B (P < 0.05). The results suggest that the treatment with PGE1 might improve hepatic function, and resist the hepatic fibrosis in patients with chronic hepatitis B.