注射型组织再生支架的研究进展

在组织修复与再生中,可注射型支架具有微创的优点,并能够为细胞的增殖与分化提供更接近于天然细胞外基质的化学与物理环境。因此,相比于传统的硬支架具有更大的优势,是细胞支架的一个重要组成部分与发展方向。目前,可注射型支架材料是以水凝胶为基础,包括温敏型水凝胶、交联型水凝胶和以水凝胶为载体的混合物。这类支架已被广泛地用于骨和软骨的修复。这些支架在体内实验中表现出良好的生物和细胞相容性,能够促进组织的形成。本文综述了可注射型组织再生支架近年来的发展动向,分析了各类可注射支架的优缺点。

Research Development of Injectable Scaffolds for Tissue Regeneration

Three-dimensional cell scaffolds play an important role in tissue engineering. They can modulate cell response and guide the regeneration of tissues. Injectable scaffolds can mimic the chemical and physical environments of natural extracellular matrix, and can be easily applied in clinic with the merits of minor or nonsurgical operations. Hence, special care should be given to the use of this kind of scaffolds in tissue engineering and tissue regeneration fields. Many kinds of hydrogels such as thermal sensitive hydrogels, crosslinking hydrogels, and composites with other fillers have been used as a basic component to construct the injectable scaffolds. Most of these injectable scaffolds are applied to repair bone and cartilage. Experimental results have shown that these scaffolds present good biocompatibility and cytocompatibility. This paper reviews the development of the injectable scaffolds in recent years. The advantages and disadvantages are discussed with the suggestions for future development.