Interval sampling of breath hydrogen (H2) as an index of lactose malabsorption in lactase-deficient subjects |
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Authors: | Dr Jack D Welsh MD Donna LaVerne Payne PhD Carl Manion MD Robert D Morrison PhD Ms Mary Ann Nichols MS |
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Institution: | (1) Department of Food, Nutrition, and Institution Administration, Oklahoma State University, Stillwater, Oklahoma;(2) the Department of Statistics, Oklahoma State University, Stillwater, Oklahoma;(3) the Digestive Disease and Nutrition Section, Medical Service, Veterans Administration Hospital, Oklahoma City, Oklahoma;(4) The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;(5) Oklahoma Memorial Hospital, State of Oklahoma Teaching Hospitals, P.O. Box 26307, 73126 Oklahoma City, Oklahoma;(6) Alcon Laboratories, 6201 South Freeway, 76134 Ft. Worth, Texas |
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Abstract: | Interval sampling of breath hydrogen content was used in lactose malabsorbers: (1) to compare hydrogen responses following increasing oral doses of lactose in milk and aqueous solutions; (2) to determine the reproducibility of interval breath sampling, and (3) to compare carbohydrate malabsorption following ingestion of either regular milk or milk containingLactobacillus acidophilus. Significant differences in breath hydrogen responses due to increasing amounts of lactose in milk and aqueous solutions were observed. The individual breath hydrogen responses were reproducible using the same lactose dose on different days. There was no significant difference in breath hydrogen responses or symptoms following administration of either regular milk or milk containingLactobacillus acidophilus. Breath hydrogen sampling at intervals, as performed in these studies, provides a sensitive and reproducible index of lactose malabsorption.Supported by the Oklahoma Agricultural Experiment Station, Stillwater, Oklahoma, and the Veterans Administration. |
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