GB virus C genotype 1 is rarely transmitted vertically but acquired during infancy in West Africa |
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| Authors: | Li Chengyao Danso Kwabena Addo-Yobo Emmanuel Dompreh Albert Sarkodie Francis Owusu-Ofori Shirley Allain Jean-Pierre |
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| Affiliation: | Division of Transfusion Medicine, National Blood Service and University of Cambridge, UK. |
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| Abstract: | Paired Ghanaian plasma and cord blood from pregnant women, alongside plasma samples from children aged 1 day to 70 months, were tested for GBV-C, HIV-1 RNA loads and anti-E2. Frequency of GBV-C vertical transmission in West Africa is significantly lower than in Europe, the USA or East Asia where genotype 2 or 3 is prevalent. While horizontal transmission appears predominant in West Africa, the lower viral load of African genotype 1 might explain limited vertical transmission. |
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