血清尿酸水平与冠状动脉左主干病变的相关性研究

目的 探讨血尿酸水平与冠状动脉左主干(LM)病变程度的关系. 方法根据冠状动脉造影结果将156例患者依据LM病变程度分为轻度狭窄组18例、中度狭窄组53例、重度狭窄组62例、完全闭塞组23例.分别检测每组患者血尿酸水平. 结果轻度狭窄组和中度狭窄组、重度狭窄组和完全闭塞组血尿酸水平分别为(368±56)μmol/L、(456±52)μmol/L、(486±58)μmol/L和(469±63)μmol/L,随冠状动脉左主干狭窄程度增加血尿酸水平逐渐升高(F=3.89,P=0.042),但完全闭塞组较重度狭窄组又出现血尿酸水平的下降(t=2.17,P=0.039). 结论冠心病患者的血清尿酸水平随冠状动脉左主干病变程度的加重而递增.

Analysis of relationship between serum concentration of uric acid and left main coronary artery disease

Objective To explore the relationship between serum concentration of uric acid and left main coronary artery stenosis. Methods According to the results of left main (LM) coronary stenosis angiograph, 156 patients were divided into mild (n=18), moderate (n=53), severe (n=62) LM stenosis groups, and total occlusion group (n=23). Their serum concentrations of uric acid were respectively analyzed. Results The serum concentrations of uric acid were (368±56)μmol/L in mild LM stenosis group, (456±52) μmol/L in moderate LM stenosis group. (486±58) μmol/L in severe LM stenosis group, and (469±63)μmol/L in total LM occlusion group. With the increase of left main coronary artery stenosis, the blood uric acid level increased gradually (F=3.89, P=0.042) (t=2.17,P=0.039), Blood uric acid level of total occlusion group decreosed compared with severe stenosis groups (t=2.17, P=0.039). Conclusions Blood uric acid level can be an index for evaluating the progress degree of LM coronary artery disease.