Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis |
| |
Authors: | Xavier Flávia Caló Aquino Rodini Camila Oliveira Ramalho Luciana Maria Pedreira Sarmento Viviane Almeida Nunes Fabio Daumas de Sousa Suzana Cantanhede Orsini Machado |
| |
Institution: | Department of Stomatology, Dental School, University of S?o Paulo, S?o Paulo, Brazil. f.calo@usp.br |
| |
Abstract: | Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis, and low survival. We report a case of CCOC affecting the mandible of a 39-year-old man. The tumor presented a biphasic pattern composed of clear cell nests intermingled with eosinophilic cells and separated by collagenous stroma. Immunoreactivity to cytokeratin (CK), specifically AE1/AE3 and CK 8, 14, 18, and 19 was found, as well as to epithelial membrane antigen (EMA). The tumor cells were negative for S100 protein, CK 13, vimentin, smooth muscle actin, laminin and type IV collagen. Low labeling indices for the proliferation markers Ki-67 and proliferating cell nuclear antigen and to p53 protein might predict a favorable prognosis for the lesion. A surgical resection was performed, followed by adjuvant radiotherapy. A 2-year follow-up has shown no signs of recurrence. The significance of histochemical and immunohistochemical resources in the correct diagnosis of CCOC is analyzed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|