| Bcl-x基因在紫杉醇诱导的HL-60细胞凋亡过程中的变化 |
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| 引用本文： | 周兆兰,尤学芬,陆德炎. Bcl-x基因在紫杉醇诱导的HL-60细胞凋亡过程中的变化[J]. 现代中西医结合杂志, 2003, 12(19): 2047-2048 |
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| 作者姓名： | 周兆兰 尤学芬 陆德炎 |
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| 作者单位： | 南通医学院附属医院,江苏,南通,226001 |
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| 摘 要： | 目的 研究抗微管药紫杉醇诱导HL - 6 0细胞凋亡过程中Bcl -x基因表达的变化。方法 用RT -PCR法检测药物孵育前后Bcl-x基因的表达水平。结果 在紫杉醇诱导HL - 6 0细胞凋亡过程中 ,Bcl-x1基因表达水平下降 ,而Bcl-xs 基因表达水平升高。结论 Bcl-x基因参与了紫杉醇诱导的HL - 6 0细胞凋亡的调控。
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| 关 键 词： | 紫杉醇 凋亡 Bcl-x基因 HL-60细胞 |
| 文章编号： | 1008-8849(2003)19-2047-02 |
| 修稿时间： | 2003-03-22 |
Change of Bcl-x gene in apoptosis course of HL-60 cells induced by Taxol |
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| ZHOU Zhao-lan,YOU Xue-fen,LU De-yan. Change of Bcl-x gene in apoptosis course of HL-60 cells induced by Taxol[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2003, 12(19): 2047-2048 |
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| Authors: | ZHOU Zhao-lan YOU Xue-fen LU De-yan |
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| Abstract: | Objective It is to study the change of Bcl-x gene expression in the apoptosis course of HL-60 cells induced by antimicrotubular drug Taxol. Methods Bcl-x gene expression level was examined with RT-PCR technique around drug incubating. Results The expression level of Bcl-x_1 gene decreased while that of Bcl-x_s gene increased in the apoptosis course of HL-60 cells induced by Taxol. Conclusion Bcl-x gene is concerned with the regulation and control of HL-60 cells. |
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| Keywords: | Taxol apoptosis Bcl-x gene HL-60 cell |
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