| 高效液相色谱法-二极管阵列检测器考察炎琥宁在更昔洛韦葡萄糖注射液中的配伍稳定性 |
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| 引用本文： | 郑芳,孙新建,吴进,朱雪松. 高效液相色谱法-二极管阵列检测器考察炎琥宁在更昔洛韦葡萄糖注射液中的配伍稳定性[J]. 安徽医药, 2010, 14(7): 772-774. DOI: 10.3969/j.issn.1009-6469.2010.07.013 |
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| 作者姓名： | 郑芳 孙新建 吴进 朱雪松 |
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| 作者单位： | 郧阳医学院附属东风医院药剂部,湖北,十堰,442008;郧阳医学院附属东风医院药剂部,湖北,十堰,442008;郧阳医学院附属东风医院药剂部,湖北,十堰,442008;郧阳医学院附属东风医院药剂部,湖北,十堰,442008 |
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| 摘 要： | 目的考察室温（20±1）℃下,注射用炎琥宁与更昔洛韦葡萄糖注射液配伍的稳定性,为临床合理用药提供依据。方法采用反相高效液相色谱法-二极管阵列检测器同时测定炎琥宁与更昔洛韦配伍后0-6 h内的含量变化,并观察配伍液的外观及pH值。结果6 h内混合液外观、pH及含量均无明显变化。结论在室温（20±1）℃条件下,注射用炎琥宁与更昔洛韦葡萄糖注射液6 h内可以配伍使用。
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| 关 键 词： | 高效液相色谱法-二极管阵列检测器 炎琥宁 更昔洛韦 配伍 稳定性 |
Stability of potassium sodium dehydroandrographolide succinate for injection in ganciclovir and glucose injection by HPLC-DAD |
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| ZHENG Fang,SUN Xin-jian,WU Jin,ZHU Xue-song. Stability of potassium sodium dehydroandrographolide succinate for injection in ganciclovir and glucose injection by HPLC-DAD[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(7): 772-774. DOI: 10.3969/j.issn.1009-6469.2010.07.013 |
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| Authors: | ZHENG Fang SUN Xin-jian WU Jin ZHU Xue-song |
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| Affiliation: | ZHENG Fang,SUN Xin-jian,WU Jin,ZHU Xue-song(Department of Pharmacy,Dengfeng General Hospital,Yunyang Medical College,Shiyan,Hubei 442008,China) |
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| Abstract: | Aim To study the stability of potassium sodium dehydroandrographolide succinate for injection in ganciclovir and glucose injection at ambient temperature(20±1)℃ in order to supply evidence for clinical rational administration.Methods The changes of the contents of potassium sodium dehydroandrographolide succinate and ganciclovir were determined simultaneously by RP-HPLC-DAD,and the changes of apperance,pH value were observed within 6 hours.Results No significant changes were found in the content,apperance and pH value for the mixed solution within 6 hours.Conclusion Potassium sodium dehydroandrographolide succinate for injection can be mixed in ganciclovir and glucose injection at ambient temperature(20±1)℃ within 6 hours. |
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| Keywords: | HPLC-DAD potassium sodium dehydroandrographolide succinate ganciclovir compatibility stability |
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