| 甲氰咪胍对非酒精性脂肪性肝炎大鼠脂质过氧化作用的影响 |
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| 引用本文： | 王旭霞,徐辉,赵曙光,王景杰,秦明,赵保民,雷巧玲,闻勤生.甲氰咪胍对非酒精性脂肪性肝炎大鼠脂质过氧化作用的影响[J].西南国防医药,2008,18(6). |
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| 作者姓名： | 王旭霞 徐辉 赵曙光 王景杰 秦明 赵保民 雷巧玲 闻勤生 |
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| 作者单位： | 第四军医大学唐都医院消化科,陕西,西安,710038 |
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| 摘 要： | 目的：探讨甲氰咪胍对非酒精性脂肪性肝炎（NASH）大鼠脂质过氧化作用的影响。方法：雄性SD大鼠30只，随机分为3组，正常对照组、模型组、甲氰咪胍组，正常组普通饲料喂养，模型组喂高脂饮食，甲氰咪胍组在高脂饮食12w后给予甲氰咪胍灌胃治疗。16w末处死各组大鼠，测定血清转氨酶（ALT、AST）、血脂（TC、TG）、肝匀浆丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性，同时测定细胞色素P450（CYP450）和细胞色素2E1（CYP2E1）含量，光镜下观察肝组织学改变。结果：与正常组比较，模型组大鼠血清TG、TC水平，肝组织脂质过氧化产物MDA含量明显增高，而抗氧化物SOD活性明显降低，肝脏的脂肪变性程度和炎症活动度均显著增高，细胞色素P450和CYP2E1含量显著增高。甲氰咪胍组各项指标较模型组有明显改善（P〈0．05）。结论：甲氰咪胍通过抑制CYP2E1表达与其密切相关的脂质过氧化作用，改善NASH大鼠脂肪变性，减轻炎症反应。
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| 关 键 词： | 甲氰眯胍 非酒精性脂肪性肝炎 脂质过氧化 |
Influence of cimetidine on lipid peroxidation in rats with nonalcoholic steatohepatitis |
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| WANG Xu-xia,XU Hui,ZHAO Shu-guang,WANG Jing-jie,QIN Ming,ZHAO Bao-min,LEI Qiao-ling,WEN Qin-sheng.Influence of cimetidine on lipid peroxidation in rats with nonalcoholic steatohepatitis[J].Medical Journal of National Defending forces in Southwest China,2008,18(6). |
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| Authors: | WANG Xu-xia XU Hui ZHAO Shu-guang WANG Jing-jie QIN Ming ZHAO Bao-min LEI Qiao-ling WEN Qin-sheng |
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| Institution: | WANG Xu-xia,XU Hui,ZHAO Shu-guang,WANG Jing-jie,QIN Ming,ZHAO Bao-min,LEI Qiao-ling,WEN Qin-sheng Department of Gastroenterology,Tangdu Hospital,Fourth Military Medical University,Xi'an,710038,China. |
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| Abstract: | Objective:To investigate effects of cimetidine on lipid peroxidation in rats with nonalcoholic steatohepatitis(NASH).Methods:30 male SD rats were randomly divided into the control group(ordinary diet),model group(high-fat diet),cimetidine treated group(intragastric administration with cimetidine after feeding high-fat diet 12 weeks).The rats in each group were killed at the end of 16 w.Blood samples were collected for the detection of serum alanine aminotransferase(ALT),aspartate transaminase(AST),total cho... |
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| Keywords: | cimetidine nonalcoholic steatohepatitis lipid peroxidation |
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