Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67 |
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Authors: | F. Giangaspero C. Doglioni M. T. Rivano S. Pileri J. Gerdes H. Stein |
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Affiliation: | (1) Istituto di Anatomia e Istologia Patologica, Universitá di Bologna, Via Massarenti 9, I-40138 Bologna, Italy;(2) Servizio di Anatomia Patologica, Ospedale Borgo Trento, I-37100 Verona, Italy;(3) Institut für Pathologie, Universität, D-2300 Kiel, Germany |
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Abstract: | Summary The monoclonal antibody Ki-67, which reacts with cells in the active part of the cell cycle, was used to evaluate immunocytochemically the growth fraction in 22 primary brain neoplasms. The percentage of labelled cells reflected the histological grade of malignancy of each neoplasms. High percentage of Ki-67-positive cells were observed in one choroid plexus carcinoma (60%), one primary melanoma of meninges (40%), three medulloblastomas (40%–50%), one anaplastic astrocytoma and six glioblastomas (10%–40%). One ependymoma had 7% positive cells. Rare positive cells (1%) were present in one pilocytic astrocytoma and one ganglioglioma. Except one negative case, the meningiomas (five cases) had values of positivity ranging from 1% to 6%. Two acoustic schwannomas were negative. These results suggest that immunocytochemical staining with the Ki-67 may be a useful method for measuring the growth fraction in brain neoplasms.Supported in part by Associazione Italiana Ricerca sul Cancro and Ministero Italiano della Pubblica Istruzione |
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Keywords: | Brain neoplasm Monoclonal antibody Ki-67 Cell kinetics Immunocytochemistry |
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