Cytotoxic constituents from Butea superba Roxb |
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| Authors: | Ngamrojanavanich Nattaya Loontaisong Aimon Pengpreecha Somchai Cherdshewasart Wichai Pornpakakul Surachai Pudhom Khanitha Roengsumran Sophon Petsom Amorn |
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| Institution: | Research Centre for Bioorganic Chemistry, Faculty of Science, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok, Thailand. nnattaya@chula.ac.th |
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| Abstract: | A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively. |
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| Keywords: | Butea superba Isoflavones Carpin Cytotoxicity |
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