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| 宁夏回族乙肝病毒基因型分布研究 | |
| 引用本文： | 杨少奇,王战会,杨力,胡建国,张栩,刘晓燕,杨文贵,许军. 宁夏回族乙肝病毒基因型分布研究[J]. 哈尔滨医科大学学报, 2006, 40(6): 474-475,485 |
| 作者姓名： | 杨少奇 王战会 杨力 胡建国 张栩 刘晓燕 杨文贵 许军 |
| 作者单位： | 1. 宁夏医学院附属医院,宁夏,银川,750004 2. 南方医科大学南方医院,感染病科,广东,广州,510000 3. 哈尔滨医科大学第四临床医学院,消化科,黑龙江,哈尔滨,150001 |
| 摘 要： | 目的 研究宁夏回族乙肝病毒(HBV)基因型分布情况.方法 选择宁夏回族HBVDNA阳性慢性乙肝病人共120例,其中病毒携带者(ASC)17例,慢性肝炎(CH)34例,肝硬化(LC)58例,肝细胞癌(HCC)11例,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测HBV基因型.结果 120例患者中B型12例(10%),C型101例(84.2%),D型5例(4.2%),C、D混合型2例(1.6%).结论 宁夏回族乙肝病毒基因型分布为C型、B型和D型,基因型C为优势基因型并与严重肝病发生有关. |
| 关 键 词： | 乙型肝炎病毒 基因型 宁夏回族 限制性片段长度多态性 |
| 文章编号： | 1000-1905（2006）06-0474-02 |
| 收稿时间： | 2005-10-27 |
| 修稿时间： | 2005-10-27 |
Distribution of hepatitis B virus genotypes in Ningxia Hui nationality people |
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| YANG Shao-qi, WANG Zhan-hui, YANG Li, et al. Distribution of hepatitis B virus genotypes in Ningxia Hui nationality people[J]. Journal of Harbin Medical University, 2006, 40(6): 474-475,485 | |
| Authors: | YANG Shao-qi WANG Zhan-hui YANG Li et al |
| Affiliation: | Department of Gastroenterology, The Affiliated Hospital of Ningxia Medical College, Yinchuan 750004, China |
| Abstract: | Objective To study the distribution of hepatitis B virus genotype in Ningxia Hui nationality people.Methods HBV genotypes were determined by the restriction fragment length polymorphism analysis in 120 HBV DNA PCR positive patients infected with hepatitis B,including 17 asymptomatic.HBV carriers(ASC),38 chronic hepatitis(CH),58 liver cirrhosis(LC) and 11 hepatocellular carcinoma patients(HCC).Results Of the 120 patients,101(84.2%)were genotype C,12(10%)were genotype B,5(4.2%)were genotype D and 2(1.6%) were infected both genotype C and D.Conclusion Hepatitis B virus genotype B,C,D coexist in Ningxia Hui nationality people,genotype C is the major genotype among than and associated with progressive liver diseases. |
| Keywords: | hepatitis B virus Hui nationality genotype restriction fragment length polymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |