全程督导与非督导治疗在初治涂阳肺结核患者临床疗效对比观察

目的对比观察我院收治初涂阳性肺结核全程督导化疗（DOTS）与非督导化疗的效果。方法将204例初涂阳性的肺结核患者随机分为全程督导组（102例）和非全程督导组（102例）,均采用2HRZE/4HR方案,非全程督导组是将一个疗程的药物一次性发给患者,而全程督导组每次服药都采用＂送药到手,看服到口,咽下再走＂的全程督导治疗,并对2组患者进行随访观察。结果化学治疗疗程结束后全程督导组痰夜涂片检查痰菌转阴率为91.40%,非全程督导组痰菌转阴率为76.09%;X线胸片检查,全程督导组吸收有效率为93.55%,非全程督导组吸收有效率为68.48%,P〈0.05,2组比较存在显著性差。随访2年全程督导组的复发率为3.7%,非全程督导组为16.9%。结论初治痰夜涂片阳性的肺结核在全程督导下进行化学药物治疗疗效确切,值得临床推广应用。

The Full Supervision R and the Non-Full Supervision Treatment in Patients with Tuberculosis Treated First Smear Positive Case Observed Clinical Curative Effect

Objective To observe the beginning of our hospital full supervision of chemotherapy smear-positive pulmonary tuberculosis（DOTS） and non-supervisory chemotherapy.Methods 204 cases of smear-positive tuberculosis patients early into full supervision of a random group（102 cases） and non-full steering group（102 cases）,are used 2HRZE/4HR programs,non-full steering group is to send a one-time course of drug to patients,while the full steering group for each drug are used ＂to send medicine hand,look at service to the mouth,swallow longer follow＂ the full supervision of treatment,and patients were followed up.Results After chemotherapy treatment throughout the night of the Steering Group sputum smear negative sputum was 91.40%,non-full steering group was sputum negative 76.09%;X-ray examination,the whole effective rate of absorption of the Steering Group 93.55%,effective absorption of non-full steering group was 68.48%,P0.05,two groups there was a significant difference.Follow-up of the Steering Group throughout the year recurrence rate was 3.7%,non-full steering group was 16.9%.Conclusion Phlegm night early in the whole smear positive pulmonary tuberculosis under the supervision of chemotherapy is effective,worthy of clinical application.