| 肝组织中丙型肝炎病毒抗原的表达及其临床意义 |
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| 引用本文： | 袁和俊,胡德昌,翟为溶. 肝组织中丙型肝炎病毒抗原的表达及其临床意义[J]. 中华传染病杂志, 1998, 16(1): 8-10 |
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| 作者姓名： | 袁和俊 胡德昌 翟为溶 |
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| 作者单位： | 上海医科大学中山医院，上海医科大学，中国科学院上海细胞生物学研究所 |
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| 摘 要： | 目的研究肝炎患者肝组织中丙型肝炎病毒抗原的表达及其临床意义。
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| 关 键 词： | 丙型肝炎病毒 免疫组织化学 抗原 |
Expression of hepatitis C virus nonstructure 4 antigen in liver tissue from patients with hepatitis |
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| Yuan Hejun,Hu Dechang,Zhai Weirong,et al.. Expression of hepatitis C virus nonstructure 4 antigen in liver tissue from patients with hepatitis[J]. Chinese Journal of Infectious Diseases, 1998, 16(1): 8-10 |
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| Authors: | Yuan Hejun Hu Dechang Zhai Weirong et al. |
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| Affiliation: | Yuan Hejun,Hu Dechang,Zhai Weirong,et al. Department of gastroenterology,Zhongshan hospital,Shanghai Medical University,Shanghai 200032 |
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| Abstract: | Objective To investigate the expression of HCV NS4 antigen in liver tissue and its clinical significance. Methods We detected 77 liver spicimens from patients with hepatitis by immunohistochemical method with monoclonal antibody to HCV NS4. Results HCV Ag were presented as granule in the cytoplasm of liver cell. The HCV Ag positive hepatocytes were found to distribute sporadically or clustering in the liver tissue from acute and chronic hepatitis patients and diffusely in the liver tissue from chronic fulminant hepatitis patients. HCV Ag positive staining was found in liver tissue from 12 of 15 patients with both HCV Ab and HCV RNA seropositive, whereas 3 of 11 patients with HCV Ab seropositive only. Conclusion The results suggested that the expression of hepatic HCV Ag had distinct relationship with the level of serum HCV RNA, and might take part in the pathogenesis of HCV. |
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| Keywords: | Hepatitis C virus Immunohistochemistry |
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