环境真菌链格孢霉对小鼠Th1/Th2平衡及气道反应性的影响 |
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引用本文: | 陈萍,;黄文婷,;邓丽侠,;鄢洁兰,;邓茂先. 环境真菌链格孢霉对小鼠Th1/Th2平衡及气道反应性的影响[J]. 青岛医药卫生, 2014, 0(3): 179-183 |
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作者姓名: | 陈萍, 黄文婷, 邓丽侠, 鄢洁兰, 邓茂先 |
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作者单位: | [1]资阳市人民医院呼吸内科,四川资阳641301; [2]四川大学华西医学中心;,四川资阳641301; [3]江苏农林职业技术学院,四川资阳641301; |
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摘 要: | 目的 探讨环境真菌链格孢霉(Alt,Alternaria)对小鼠Th1/Th2平衡及气道反应性的影响.方法 通过将小鼠暴露于链格孢霉提取物建立小鼠模型,以鸡卵蛋白(OVA)为阳性对照,探索真菌链格孢霉对Th1/Th2平衡及哮喘特征性指标的影响.结果 与OVA相似,Alt暴露引起了气道炎症细胞总数(P<0.01)、嗜酸性细胞数增加(P<0.01);诱导了气道敏化和Th2反应并引起肺部和支气管的病理学变化.Alt与OVA间存在协同作用.结论 实验结果表明,环境真菌可通过干扰气道Th1/Th2平衡继而导致炎症,最终引起哮喘的发生.
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关 键 词: | 哮喘 真菌 链格孢霉 Th1 Th2 |
Effects of environmental Alternaria on Th1/Th2 ratio and airway responsiveness in mice |
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Affiliation: | CHEN Ping ,HUANG Wen-ting ,DENG Li-xia, YAN Jie-lan ,DENG Mao-xian (Ziyang People's Hospital, Ziyang, Sichuan 641301, China) |
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Abstract: | Objective To investigate effects of environmental Alternaria on Thl/Th2 ratio and air-way responsiveness in mice. Methods We explored the effects of Alt on Thl/Th2 balance and specific indexes of asthma by exposing mice to fungal extract of Alt to establish mouse model, and using OVA-treated group as the positive control. Results Alt, like OVA, increased number of inflammatory cells (P 〈 0.01) and eosinophils (P 〈 0.01) in bronchoalveolar lavage fluid (BALF), and induced airway sensitization and Th2-like immune responses and thereby pathological changes in lungs and bronchi. A synergistic effect between Alt and OVA was also observed. Conclusion The results show that environmental fungi may disrupt the Th1/Th2 balance and thereby results bronchial inflammation and asthma. |
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Keywords: | Asthma Fungus Alternaria Th1/Th2 |
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