哮喘患儿皮肤点刺试验反应强度与呼气一氧化氮和肺功能的关系

目的 将不同阳性级别过敏原皮肤点刺试验（Skin prick test,SPT）哮喘儿童的呼气一氧化氮（FeNO）和肺功能进行比较,探讨皮肤点刺试验反应强度与呼气一氧化氮和肺功能的关系.方法 回顾分析进行了过敏原SPT的哮喘患儿94例,根据屋尘螨和粉尘螨反应强度分为3组：SPT结果为（＋＋＋）～（＋＋＋＋）患儿33例为A组,SPT结果为（＋）～（＋＋）患儿31例为B组,SPT结果为（-）患儿30例为C组,评价患儿FeNO和FEV1/FVC百分比.结果 3组患儿FEV1/FVC百分比分别为A组（94.00±6.46）、B组（96.46±5.12）和C组（95.76±6.19）,差异无统计学意义（P＞0.05）.3组FeNO值分别为A组（57.96±20.06） ppb、B组（42.72±14.07）ppb和C组（30.54±14.63）ppb,差异有统计学意义（P＜0.05）,且随着SPT中变应原反应强度增加而增加.结论 呼气一氧化氮能较好地反映过敏性哮喘患儿的气道炎症,明显优于肺功能检查,可用于过敏性哮喘的诊断和气道炎症的评估.

Relationship between skin prick test and the fractional exhaled nitric oxide and pulmonary function in asthmatic children

Objective To investigate the relationship between different positive skin prick test （SPT） grades and FeNO and pulmonary function in asthmatic children. Methods According to different positive skin prick test grades, 94 children with mild to moderate asthma were randomized into three groups. 34 children of （＋ ＋ ＋） to （＋＋＋＋） SPT results were distributed to group A, 31 children of （＋） to （＋＋） SPT result to group B and 31 children of （--） SPT result to group C. FeNO and FEV1% levels were measured in group A, group B and group C, and statistically analyzed. Results The FEV1% levels of three group were group A（94.00 ± 6.46）, group B（96.46 ± 5.12） and group C（95.76 ! 6.19）, respectively. No significant difference was found among three groups in the pulmonary functions （ P 〉 0. 05 ）. The FENO levels of three groups were group A （57.96 ± 20. 06）ppb, group B （42.72 ± 14.07）ppb and group C （30.54 ± 14.63）ppb, respectively. There was statistically significant difference between three groups in FeNO levels（P〈0.05）. FENO levels increased with increased reaction intensity of SPT. Conclusion FeNO can reflect airway inflammation in children with allergic asthma, significantly better than the pulmonary function test, and can be used for the diagnosis and evaluation of airway inflammation in allergic asthma.