| 一株拟茎点霉属中新的色原烯及其肿瘤细胞抑制活性研究 |
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| 引用本文： | 杨志钧,殷瑜,戈梅. 一株拟茎点霉属中新的色原烯及其肿瘤细胞抑制活性研究[J]. 中国中药杂志, 2015, 40(4): 667-671 |
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| 作者姓名： | 杨志钧 殷瑜 戈梅 |
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| 作者单位： | 上海交通大学 药学院, 上海 200040,上海交通大学 药学院, 上海 200040,上海来益生物药物研究开发中心, 上海 200240 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2012ZX09301-002-004) |
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| 摘 要： | 为了研究拟茎点霉属真菌HCCB03519的大米发酵产物的肿瘤细胞抑制活性成分,对其进行了化学研究和肿瘤细胞抑制活性分析。从其乙酸乙酯浸提部分分离得到7个化合物,经波谱数据分析,鉴定为phomochromene(1),6-羟基蜂蜜曲霉素(2),6-羟基-5-甲基蜂蜜曲霉素(3),nectriapyrone(4),chermesinone A(5),chermesinone B(6),pomopxanthone A(7),其中化合物1为一个新的色原烯,化合物5和6为首次在拟茎点霉属中发现。肿瘤抑制活性分析表明,化合物1~6对各个肿瘤细胞的抑制活性较低,化合物7具有较强的抑制活性,比阳性对照5-Fu的抑制活性高。
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| 关 键 词： | 拟茎点霉属 色原烯 肿瘤细胞抑制活性 |
| 收稿时间： | 2014-10-24 |
A novel chromene with anti-tumor activities from fungus Phomopsis sp. |
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| YANG Zhi-jun,YIN Yu and GE Mei. A novel chromene with anti-tumor activities from fungus Phomopsis sp.[J]. China Journal of Chinese Materia Medica, 2015, 40(4): 667-671 |
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| Authors: | YANG Zhi-jun YIN Yu GE Mei |
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| Affiliation: | School of Pharmacy, Shanghai Jiaotong University, Shanghai 200040, China,School of Pharmacy, Shanghai Jiaotong University, Shanghai 200040, China and Shanghai Health Creation Center for Biopharmaceuticals R&D, Shanghai 200240, China |
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| Abstract: | A new chromene (1) and six known compounds identified as 6-hydroxymellein(2), 6-hydroxy-5-methylmellein(3), nectriapyrone(4), chermesinone A(5), chermesinone B(6), and pomopxanthone A(7), were isolated in our investigation of the cytotoxic constituents from the fermented rice substrate of endophytic fungus Phomopsis sp. HCCB03519. The structures of these compounds were elucidated through spectroscopic data analysis. All compounds exhibited inhibitory activities against cancer cell lines. Compound 7 showed stronger inhibition against cancer cells than the positive control 5-Fu. |
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| Keywords: | Phomopsis sp. phomochromene anti-tumor activity |
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