| 中药成分的生物学活性评价及筛选 |
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| 引用本文： | 李建锋,荀丽英,李航,赵启韬. 中药成分的生物学活性评价及筛选[J]. 中草药, 2015, 46(4): 588-594 |
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| 作者姓名： | 李建锋 荀丽英 李航 赵启韬 |
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| 作者单位： | 山东中医药大学药学院, 山东 济南 250355;山东中医药大学基础医学院, 山东 济南 250355;山东中医药大学药学院, 山东 济南 250355;山东中医药大学基础医学院, 山东 济南 250355 |
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| 基金项目： | 国家自然科学基金资助项目(81173164) |
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| 摘 要： | 中药成分的生物学活性评价是探索中药药效物质基础的主要手段。分别从整体动物、细胞、分子3个层面,系统论述了10年来该领域的技术进展,以及依托新技术筛选出的新中药活性组分及单体化合物。同时分析了不同技术的长处及不足,以期能为中药新药研发提供资料及思路。
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| 关 键 词： | 中药活性成分 生物学活性评价 膜亲和色谱 生物大分子亲和色谱 高效液相色谱-柱后生物活性联机检测 |
| 收稿时间： | 2014-11-19 |
Evaluation and screening for biological activity of components in Chinese materia medica |
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| LI Jian-feng,XUN Li-ying,LI Hang and ZHAO Qi-tao. Evaluation and screening for biological activity of components in Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2015, 46(4): 588-594 |
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| Authors: | LI Jian-feng XUN Li-ying LI Hang ZHAO Qi-tao |
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| Affiliation: | College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;College of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;College of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China |
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| Abstract: | Biological activity evaluation of Chinese materia medica (CMM) composition is one of the main means to explore the active components of CMM. This paper, from the three aspects of whole animal, cellular, and molecular, discusses systematically the technical progress in this area over the past 10 years and the screening of new active ingredients from CMM and monomer compounds based on new technology. At the same time, the different technical strengths and weaknesses have been analyzed in the hope of providing the information and ideas for the research on the new drugs of CMM. |
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| Keywords: | bioactive components in Chinese materia medica biological activity evaluation membrane affinity chromatography biomacromoleculer affinity chromatography high performance liquid chromatography-biological activity after column on-line detection |
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