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| 酸枣仁皂苷A对大鼠心室肌细胞L-型钙通道的影响 | |
| 引用本文： | 邓伟,唐其柱,李欣,尹小菲,郭海鹏,郭凯,冯斯婷,黄觊.酸枣仁皂苷A对大鼠心室肌细胞L-型钙通道的影响[J].武汉大学学报(医学版),2009,30(3). |
| 作者姓名： | 邓伟 唐其柱 李欣 尹小菲 郭海鹏 郭凯 冯斯婷 黄觊 |
| 作者单位： | 1. 武汉大学人民医院心内科,湖北,武汉,430060;湖北省荆州市中心医院,湖北,荆州,434020 2. 武汉大学人民医院心内科,湖北,武汉,430060 3. 湖北省荆州市中心医院,湖北,荆州,434020 |
| 基金项目： | 武汉市科技重点项目(编号:20053050022) |
| 摘 要： | 目的:研究酸枣仁皂苷A对大鼠单个心室肌细胞膜L-型钙电流(ICa-L)通道的影响。方法:采用全细胞膜片钳技术,观察不同浓度的酸枣仁皂苷A对ICa-L的作用。结果:①酸枣仁皂苷A对ICa-L呈浓度依赖性抑制。②100 mg/L酸枣仁皂苷A能使ICa-LI-V曲线明显上移。③100 mg/L酸枣仁皂苷A能使ICa-L稳态激活曲线右移,稳态失活曲线左移,还能增加失活后恢复的τ值。结论:提示酸枣仁皂苷A能够影响ICa-L通道的激活态和失活态抑制ICa-L。 |
| 关 键 词： | 酸枣仁皂苷A L-型钙电流 全细胞膜片钳 心室肌 大鼠 |
Inhibitory Effect of Jujuboside A on L-type Calcium Currents in Ventricular Myocytes of Rats |
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| DENG Wei,TANG Qizhu,LI Xin,YIN Xiaofei,GUO Haipeng,GUO Kai,FENG Siting,HUANG ji.Inhibitory Effect of Jujuboside A on L-type Calcium Currents in Ventricular Myocytes of Rats[J].Medical Journal of Wuhan University,2009,30(3). | |
| Authors: | DENG Wei TANG Qizhu LI Xin YIN Xiaofei GUO Haipeng GUO Kai FENG Siting HUANG ji |
| Institution: | DENG Wei1,2,TANG Qizhu1,LI Xin2,YIN Xiaofei1,GUO Haipeng1,GUO Kai1,FENG Siting1,HUANG Ji1 1Dept.of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China2Dept.of Cardiology,Jingzhou Central Hospital of Hubei Province,Jingzhou 434020,China |
| Abstract: | Objective: To study the effects of Jujuboside A(JuA) on ICa-L in rat ventricular myocytes.Methods: Standard whole-cell patch clamp technique was adopted.Results: ①JuA reduced ICa-L in a concentration-dependent manner.②JuA in the concentration of 100 mg/L could make the I-V curves upward.③JuA in the concentration of 100 mg/L made the steady-state activation curves shift to right,the steady-state inactivation curve to left,and the tau value of recovery duration increased obviously.Conclusion: JuA inhibits the L-type calcium channel by influencing activated states and inactivated states. |
| Keywords: | Jujuboside A L-Type Calcium Currents Patch Clamp Ventricular myocytes Rats |
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