藿香正气液对大鼠P物质的影响

目的:观察藿香正气液对大鼠P物质(SP)的影响。方法:将大鼠随机分为实验(藿香正气液)组和对照(生理盐水)组,分别灌胃相应药物1h、6h后观察大鼠胃肠动力的变化,测定血浆、胃窦和空肠组织匀浆中SP的含量及观察胃窦、空肠组织中SP阳性产物的分布情况。结果:实验组用药后大鼠胃肠动力显著增强,以用药后1h作用更明显;与对照组比较,实验组血浆、胃窦及空肠组织匀浆中SP含量及胃窦和空肠组织中SP阳性产物含量明显增加(P<0.05或P<0.01)。结论:藿香正气液促胃动力作用可能与其对SP的影响有关。

Effect of Huoxiangzhengqi Liquid on Substance P of Rats

OBJECTIVE:To observe the effect of huoxiangzhengqi liquid on substance P(SP)of rats.METHODS:The rats were randomly divided into trial group(huoxiangzhengqi liquid)and control group(normal saline),the gastrointestinal motility of rats were observed1hour and6hours after drenched with the corresponding drugs,levels of SP in serum,sinus ventriculi,jejunum tissues homogenate and the distributions of SP positive products in sinus ventriculi and jejunum tissues of2groups of rats were also determined.RESULTS:The gastrointestinal motility of the trial group was markedly enhanced after medication,particularly1hour after medication;Compared with the control group,levels of SP in serum,sinus ventriculi,jejunum tissues homogenate and SP positive products in sinus ventriculi,jejunum tissues had a significant increase in the trial group(P<0.05or P<0.01).CONCLUSION:The promotion effect of huoxiangzhengqi liquid on gastrointestinal motility is probably related to its effect on SP.