| 高效液相色谱法测定5-Fu透皮给药后的血药浓度 |
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| 引用本文： | 段更利,陆明廉,邓大明. 高效液相色谱法测定5-Fu透皮给药后的血药浓度[J]. 中国临床药学杂志, 1994, 0(3) |
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| 作者姓名： | 段更利 陆明廉 邓大明 |
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| 作者单位： | 上海医科大学药学院分析化学教研室 200032(段更利，陆明廉)，上海医科大学药学院 药学专业88届毕业生(邓大明) |
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| 摘 要： | 本文建立了高效液相色谱法测定5-Fu透皮给药后血浓度的方法。方法回收率为101.8％,线性范围50～1100ng/ml血浆(r=0.9995)。天内天间精密度小于1.88％。检测限为3ng,用本法测定了家兔5-Fu透皮给药后的血浓度。
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| 关 键 词： | 5-氟脲嘧啶 透皮给药 高效液相色谱法 |
HPLC FOR 5-FLUOROURACIL IN PLASMA AFTER TRANSDERMAL ADMINISTRATION |
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| Duan Gengli Lu Minglian Deng Daming. HPLC FOR 5-FLUOROURACIL IN PLASMA AFTER TRANSDERMAL ADMINISTRATION[J]. Chinese Journal of Clinical Pharmacy, 1994, 0(3) |
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| Authors: | Duan Gengli Lu Minglian Deng Daming |
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| Abstract: | 5-Fluorouracil in plasma after transdermal administration in rabbits was determined by HPLC. The linear range was 50 -1100ng/ml plasma (r>0.9995 ). The detection limit was 3ng. The CV of within day and between day were1.88% and 1. 22% respectively. The recovery of 5-Fu in plasma was 101. 8%. This method may be used successfully in all the studies of 5-Fu's transdermal delivery system. |
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| Keywords: | 5-Fluorouracil trasdermal delivery system HPLC |
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