Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway |
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| Authors: | Rosanna Vaschetto René JP Musters Etto C Eringa Francesco Della Corte Kanneganti Murthy AB Johan Groeneveld Frans B Plötz |
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| Affiliation: | (1) Department of Clinical and Experimental Medicine, University of Eastern Piedmont "Amedeo Avogadro", Corso Mazzini 18, 28100 Novara, Italy;(2) Department of Pediatric Intensive Care, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(3) Department of Intensive Care, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(4) Institute for Cardiovascular Research, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(5) Department of Physiology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;(6) Inotek Pharmaceuticals Corporation, 33 Hayden Avenue, 0242 Lexington, MA, USA |
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| Abstract: | Introduction Mechanical ventilation (MV) can injure the lungs and contribute to an overwhelming inflammatory response, leading to acute renal failure (ARF). We previously showed that poly(adenosine diphosphate-ribose) polymerase (PARP) is involved in the development of ventilator-induced lung injury (VILI) and the related ARF, but the mechanisms underneath remain unclear. In the current study we therefore tested the hypothesis that renal blood flow and endothelial, functional and tissue changes in the kidney of rats with lipopolysaccharide (LPS)-induced lung injury aggravated by MV, is caused, in part, by activation of PARP by peroxynitrite. |
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