| CD44v6在妊娠滋养细胞疾病中的表达及其对葡萄胎恶变预测的价值 |
| |
| 引用本文： | 张铨富,李英勇,王晨虹,王楚莹,林胜谋,涂新枝.CD44v6在妊娠滋养细胞疾病中的表达及其对葡萄胎恶变预测的价值[J].中国妇幼保健,2010,25(7). |
| |
| 作者姓名： | 张铨富 李英勇 王晨虹 王楚莹 林胜谋 涂新枝 |
| |
| 作者单位： | 1. 南方医科大学附属深圳妇幼保健院,518028
2. 广东医学院附属医院 |
| |
| 摘 要： | 目的:探讨妊娠滋养细胞疾病(GTD)细胞黏附分子CD44v6(CD44v6)表达特征及其对葡萄胎恶变预测的价值。方法:采用免疫组织化学(immunohistochemisty)法对60例GTD组织和10例正常早孕绒毛组织CD44v6进行半定量检测。结果:GTD组织和正常早孕绒毛组织均表达CD44v6,在GTD中的表达水平显著高于正常早孕绒毛组,在完全性葡萄胎中CD44v6的表达水平显著高于部分性葡萄胎(P0.05)。日后恶变组葡萄胎CD44v6表达量显著高于非恶变组葡萄胎(P0.01)。结论:完全性葡萄胎中CD44v6的表达水平显著高于部分性葡萄胎,恶变组葡萄胎CD44v6表达量显著高于非恶变组葡萄胎,可能与葡萄胎恶变有关,对葡萄胎恶变的预测有一定的价值。
|
| 关 键 词： | 妊娠滋养细胞疾病 CD44v6 免疫组织化学 |
Expression of CD44v6 in gestational trophoblastic disease and its value in prognosis of carcinomatous change of hydatidiform mole |
| |
| ZHANG Quan-Fu,LI Ying-Yong,WANG Chen-Hong et al.Shenzhen Maternal , Child Health Hospital Affiliated to South Medical University,Shenzhen ,Guangdong,China.Expression of CD44v6 in gestational trophoblastic disease and its value in prognosis of carcinomatous change of hydatidiform mole[J].Maternal and Child Health Care of China,2010,25(7). |
| |
| Authors: | ZHANG Quan-Fu LI Ying-Yong WANG Chen-Hong Shenzhen Maternal Child Health Hospital Affiliated to South Medical University Shenzhen Guangdong China |
| |
| Institution: | ZHANG Quan-Fu,LI Ying-Yong,WANG Chen-Hong et al.Shenzhen Maternal , Child Health Hospital Affiliated to South Medical University,Shenzhen 518028,Guangdong,China |
| |
| Abstract: | Objective:To explore the expression characteristics of CD44v6 in gestational trophoblastic disease(GTD) and its value in prognosis of carcinomatous change of hydatidiform mole.Methods:The expression levels of CD44v6 in GTD tissues from 60 patients with GTD and chorionic villi tissues from 10 healthy women of early pregnancy were detected by immunohistochemisty.Results:CD44v6 was detected in normal chorion villi tissues and GTD tissues.The expression level of CD44v6 in GTD tissues was significantly higher th... |
| |
| Keywords: | Gestational trophoblastic disease CD44v6 Immunohistochemisty |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
